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KMID : 1039420230570060332
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Journal of Pathology and Translational Medicine
2023 Volume.57 No. 6 p.332 ~ p.336
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Intravascular NK/T-cell lymphoma: a case report and literature review
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Na Ji-Min
Jung Wook-Jae
Kim Min-Hye
Cheon Yun-Hong
Lee Jong-Sil
Song Dae-Hyun
Yang Jung-Wook
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Abstract
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Intravascular lymphoma is characterized by an exclusively intravascular distribution of tumor cells. Intravascular natural killer/T-cell lymphoma (IVNKTL) is extremely rare, highly aggressive, commonly Epstein-Barr virus (EBV)?positive, and predominantly affects the skin and central nervous system. Here we report a case of IVNKTL diagnosed in a 67-year-old female, presenting with persistent intermittent fever and skin rashes throughout the body. Incisional biopsy of an erythematous lesion on the chest exhibited aggregation of medium to large-sized atypical lymphoid cells confined to the lumen of small vessels that were positive for CD3, granzyme B, and CD56 on immunohistochemistry and EBV-encoded RNA in situ hybridization. EBV DNA was also detected in serum after diagnosis. With a review of 26 cases of IVNKTL to date, we suggest that active biopsy based on EBV DNA detection may facilitate early diagnosis of IVNKTL.
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KEYWORD
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Malignant lymphoma, Extranodal NK-T-cell lymphoma, Epstein-Barr virus
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